Endocrine disruptors affect developmental programming of HOX gene expression
نویسندگان
چکیده
منابع مشابه
Cancer and developmental exposure to endocrine disruptors.
Developing organisms have increased susceptibility to cancer if they are exposed to environmental toxicants during rapid growth and differentiation. Human studies have demonstrated clear increases in cancer after prenatal exposure to ionizing radiation, and there is suggestive evidence that brain tumors and leukemia are associated with parental exposures to chemicals. Animal experiments have de...
متن کاملEndocrine Disruptors
Law and science combine in the estimation of risks from endocrine disruptors (EDs) and actions for their regulation. For both, dose–response models are the causal link between exposure and probability (or percentage change) of adverse response. The evidence that leads to either regulations or judicial decrees is affected by uncertainty and limited knowledge, raising difficult policy issues that...
متن کاملEndocrine Disruptors and Obesity
PURPOSE OF REVIEW The purpose of this review was to summarise current evidence that some environmental chemicals may be able to interfere in the endocrine regulation of energy metabolism and adipose tissue structure. RECENT FINDINGS Recent findings demonstrate that such endocrine-disrupting chemicals, termed "obesogens", can promote adipogenesis and cause weight gain. This includes compounds ...
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Endometriosis is an estrogen-dependent disease, which involves the growth of endometrial tissue outside the uterine cavity, commonly in the pelvic region. The etiology of the disease is unclear, but multiple factors may contribute to its prognosis. Toxicological studies indicate that many chemicals are able to interfere with endocrine homeostasis, called endocrine disrupting chemicals (EDC) lik...
متن کامل[Endocrine disruptors: mechanism of action].
<要 約> 内分泌撹乱化学物質, いわゆる 「環境ホルモン」の生体作用の特徴, その対象 として想定され ている化学物質, ならびに現時点での問題点について概説 した.“内分泌ホルモン様の機能”を もつ化学物質 としてのこれ らの物質の生体作用の特徴は, 受容体原性の作用 に性質が集約 される. そこにある問題点は, まず第1に 閾値問題, すなわち受容体原性の障害発症機構に起因する極微量反応性の問題, 第2に 低用量問 題, すなわちおそらく受容体のリダンダンシーなどの分子機構 に関わると思われる, 低用量域ではっきりし ない用量相関問題, 第3に 受容体 シグナルの伝達機構に関わる 「相乗 ・相加効果」の問題, そ して, 第4に, 胎生期の特定な時期に高い感受性 を呈 して後世代影響へ とつながる, いわゆる 「胎生期ウィンドウ」の問題 である. この他, 受容体のプレイオ ト...
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ژورنال
عنوان ژورنال: Fertility and Sterility
سال: 2008
ISSN: 0015-0282
DOI: 10.1016/j.fertnstert.2007.12.030